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KMID : 0370219850290030124
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Yakhak Hoeji
1985 Volume.29 No. 3 p.124 ~ p.129
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Studies on the Dissolution Rate of Phenylbutazone Deposited on Excipients by Solvent Deposition Method
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용재익/Yong JI
손영옥/Son YO
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Abstract
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A dissolution characteristics of phenylbutazone deposited on Avicel and dibasic calcium phosphate by solvent deposition method were studied. The solvent deposition was confirmed by scanning electron microscopy. Avicel was superior to dibasic calcium phosphate as excipient in dissolution rate. Total amount of phenylbutazone dissolved from Avicel deposition system at 30 minutes were enhanced 1.2~1.6 times compared with physical mixtures of them. The dissolution rate of 10% solvent deposition system was highest and that of 75% solvent deposition system was lowest in Avicel system and dibasic calcium phosphate system. Dissolution profile of commercial products was dependent on manufacturing conditions and dissolution rate of 10% Avicel system was greater than that of commercial products.
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